反应详情

温度

0 °C

To a solution of (3-benzyloxy-2-methyl-phenyl)-methanol (57, 627 mg, 2.75 mmol) in tetrahydrofuran (60 mL) was added Dess-Martin periodinane (2.9 g, 6.87 mmol) at 0° C. The resulting mixture was stirred at 0° C. for 50 minutes. The reaction mixture was quenched with a solution of saturated sodium thiosulfate, extracted with ethyl acetate, washed with sodium bicarbonate, brine, and dried over magnesium sulfate. After removal of solvent, the residue was purified by silica gel column chromatography eluting with ethyl acetate in hexane to provide the compound as a white solid (58, 0.55 g, 84%).

1. customThe reaction mixture was quenched with a solution of saturated sodium thiosulfate
2. extractionextracted with ethyl acetate
3. washwashed with sodium bicarbonate, brine
4. dry with materialdried over magnesium sulfate
5. customAfter removal of solvent
6. customthe residue was purified by silica gel column chromatography
7. washeluting with ethyl acetate in hexane