反应详情

温度

0 °C

To a solution of [3-benzyloxy-2-cyclopropylmethoxy-phenyl]-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol (131, 0.99 g, 2.28 mmol) in tetrahydrofuran (120 mL), Dess-Martin periodinane (2.4 g, 5.69 mmol) was added at 0° C. The reaction mixture was stirred at 0° C. for 50 minutes. The reaction was quenched with a saturated solution of sodium thiosulfate, extracted with ethyl acetate, washed with sodium bicarbonate, brine, and dried over magnesium sulfate. After removal of solvent, the residue was dried over vacuum to provide the compound as a yellow solid (132, 0.92 g, 93%).

1. customThe reaction was quenched with a saturated solution of sodium thiosulfate
2. extractionextracted with ethyl acetate
3. washwashed with sodium bicarbonate, brine
4. dry with materialdried over magnesium sulfate
5. customAfter removal of solvent
6. customthe residue was dried over vacuum