Sodium Hydroxide → HCID 66857257, compound

HRID 253483Notes

Reaction equation

HRID 253483 reaction equation
[OH-].[Na+].[CH2:3]([NH:5][CH:6]([CH2:41][CH3:42])[CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([O:24]CC)=[O:23])=[CH:18][CH:17]=2)=[CH:12][C:11]=1[C:27]1[CH:36]=[CH:35][C:34]2[C:33]([CH3:38])([CH3:37])[CH2:32][CH2:31][C:30]([CH3:40])([CH3:39])[C:29]=2[CH:28]=1)[CH3:4]>O1CCCC1>[CH2:3]([NH:5][CH:6]([CH2:41][CH3:42])[CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=2)=[CH:12][C:11]=1[C:27]1[CH:36]=[CH:35][C:34]2[C:33]([CH3:38])([CH3:37])[CH2:32][CH2:31][C:30]([CH3:40])([CH3:39])[C:29]=2[CH:28]=1)[CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66857025HCID 66857025, compound

Product 1

HCID 66857257HCID 66857257, compoundYield 89.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to that of Example 2a, by reaction of 250 mg (6.25 mmol) of sodium hydroxide with 340 mg (0.63 mmol) of ethyl 4′-(3-ethylaminopentyloxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate (Example 21 b) in 30 ml of tetrahydrofuran. 290 mg of 4′-(3-ethylaminopentyloxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid are obtained in the form of a white solid (m.p.=195° C., yield=90%).

Sources & evidence

ORD record
ord-e6d6760ff92e475ba2551b69bb4e0a63
Source dataset
uspto-grants-2011_01
Patent number
US07872026B2

Reaction notes

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