Sodium Hydroxide → HCID 66856294, compound

Participants

Reaction Steps

In a manner similar to that of Example 2a, by reaction of 130 mg (3 mmol) of sodium hydroxide with 180 mg (0.3 mmol) of ethyl 4′-(4-cyclopropylaminobutoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate (Example 11) in 30 ml of tetrahydrofuran. 95 mg of 4′-(4-cyclopropylaminobutoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid are obtained in the form of a white solid (m.p.=160° C., yield=62%).

Provenance & Evidence