Sodium Hydroxide → HCID 66856294, compound

HRID 253497Notes

Reaction equation

HRID 253497 reaction equation
[OH-].[Na+].[CH:3]1([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([O:26]CC)=[O:25])=[CH:20][CH:19]=3)=[CH:14][C:13]=2[C:29]2[CH:38]=[CH:37][C:36]3[C:35]([CH3:40])([CH3:39])[CH2:34][CH2:33][C:32]([CH3:42])([CH3:41])[C:31]=3[CH:30]=2)[CH2:5][CH2:4]1>O1CCCC1>[CH:3]1([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([OH:26])=[O:25])=[CH:20][CH:19]=3)=[CH:14][C:13]=2[C:29]2[CH:38]=[CH:37][C:36]3[C:35]([CH3:40])([CH3:39])[CH2:34][CH2:33][C:32]([CH3:42])([CH3:41])[C:31]=3[CH:30]=2)[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66856876HCID 66856876, compound

Product 1

HCID 66856294HCID 66856294, compoundYield 61.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to that of Example 2a, by reaction of 130 mg (3 mmol) of sodium hydroxide with 180 mg (0.3 mmol) of ethyl 4′-(4-cyclopropylaminobutoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate (Example 11) in 30 ml of tetrahydrofuran. 95 mg of 4′-(4-cyclopropylaminobutoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid are obtained in the form of a white solid (m.p.=160° C., yield=62%).

Sources & evidence

ORD record
ord-ccb9163161ab4fd9b97ab61549222474
Source dataset
uspto-grants-2011_01
Patent number
US07872026B2

Reaction notes

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