反应详情

600 mg (2.24 mmol) of N-(3-bromopropyl)phthalimide and 310 mg (2.24 mmol) of potassium carbonate are added to a solution of 800 mg (1.86 mmol) of ethyl 4′-hydroxy-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate in 50 ml of acetone. The reaction mixture is stirred overnight at reflux. The reaction is stopped by adding water, and is then extracted with ethyl acetate. The organic phases are combined and dried over sodium sulfate. The solvents are evaporated off. The residue is precipitated from a small amount of ethyl acetate. It is filtered off and 700 mg of ethyl 4′-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propoxy]-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate are obtained in the form of a white solid (yield=61%).

1. temperatureat reflux
2. extractionis then extracted with ethyl acetate
3. dry with materialdried over sodium sulfate
4. customThe solvents are evaporated off
5. customThe residue is precipitated from a small amount of ethyl acetate
6. filtrationIt is filtered off