Sodium Hydroxide → HCID 66857351, compound

Participants

Reaction Steps

In a manner similar to that of Example 2a, by reaction of 300 mg (7.5 mmol) of sodium hydroxide with 410 mg (0.74 mmol) of ethyl 4′-(3-cyclopropylaminopentyloxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate (Example 21b) in 30 ml of tetrahydrofuran. 290 mg of 4′-(3-cyclopropylaminopentyloxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid are obtained in the form of a white solid (m.p.=161° C., yield=75%).

Provenance & Evidence