Sodium Hydroxide → HCID 66857351, compound

HRID 253510Notes

Reaction equation

HRID 253510 reaction equation
[OH-].[Na+].[CH:3]1([NH:6][CH:7]([CH2:42][CH3:43])[CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([O:25]CC)=[O:24])=[CH:19][CH:18]=3)=[CH:13][C:12]=2[C:28]2[CH:37]=[CH:36][C:35]3[C:34]([CH3:39])([CH3:38])[CH2:33][CH2:32][C:31]([CH3:41])([CH3:40])[C:30]=3[CH:29]=2)[CH2:5][CH2:4]1>O1CCCC1>[CH:3]1([NH:6][CH:7]([CH2:42][CH3:43])[CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][CH:18]=3)=[CH:13][C:12]=2[C:28]2[CH:37]=[CH:36][C:35]3[C:34]([CH3:38])([CH3:39])[CH2:33][CH2:32][C:31]([CH3:41])([CH3:40])[C:30]=3[CH:29]=2)[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66858394HCID 66858394, compound

Product 1

HCID 66857351HCID 66857351, compoundYield 74.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to that of Example 2a, by reaction of 300 mg (7.5 mmol) of sodium hydroxide with 410 mg (0.74 mmol) of ethyl 4′-(3-cyclopropylaminopentyloxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate (Example 21b) in 30 ml of tetrahydrofuran. 290 mg of 4′-(3-cyclopropylaminopentyloxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid are obtained in the form of a white solid (m.p.=161° C., yield=75%).

Sources & evidence

ORD record
ord-a1aa3adb601d485082b8804a16654b46
Source dataset
uspto-grants-2011_01
Patent number
US07872026B2

Reaction notes

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