反应详情

In a manner similar to that of Example 17b, by reaction of 760 mg (1.18 mmol) of ethyl 4′-[5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentyloxy]-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate with 230 μl (4.72 mmol) of hydrazine monohydrate in 50 ml of ethanol. 280 mg of ethyl 4′-(5-aminopentyloxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate are obtained in the form of a whitish solid (yield=46%).