Sodium Hydroxide → HCID 11317405, compound

HRID 253515Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21]CC)=[O:20])=[CH:15][CH:14]=2)=[CH:9][C:8]=1[C:24]1[CH:33]=[CH:32][C:31]2[C:30]([CH3:35])([CH3:34])[CH2:29][CH2:28][C:27]([CH3:37])([CH3:36])[C:26]=2[CH:25]=1.[OH-].[Na+]>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15][CH:14]=2)=[CH:9][C:8]=1[C:24]1[CH:33]=[CH:32][C:31]2[C:30]([CH3:35])([CH3:34])[CH2:29][CH2:28][C:27]([CH3:37])([CH3:36])[C:26]=2[CH:25]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 11167947HCID 11167947, compound

Product 1

HCID 11317405HCID 11317405, compoundYield 86.6%

Procedure

In a manner similar to that of Example 2a, by reaction of 300 mg (0.6 mmol) of ethyl 4′-(4-aminobutoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate with 240 mg (6 mmol) of sodium hydroxide. 245 mg of 4′-(4-aminobutoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid are obtained in the form of a white solid (m.p.=250° C., yield=86%).

Sources & evidence

ORD record: ord-ed359faf7a04481daa5244928d60aa53
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07872026B2

Reaction notes

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