Hydrochloric Acid → HCID 57419609, compound

HRID 253551Notes

Reaction equation

HRID 253551 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH:8]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH:9]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1.O1CCOCC1.[ClH:33]>>[ClH:33].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH:8]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH:9]1[CH2:13][CH2:12][NH:11][CH2:10]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 57419607HCID 57419607, compound

Product 1

HCID 57419609HCID 57419609, compound

Procedure

tert-Butyl 3-((4-methoxybutoxy)(phenyl)methyl)pyrrolidine-1-carboxylate (47 mg, 0.13 mmol) was dissolved in 4 M HCl in dioxane (4 mL, 16 mmol). The solution was stirred at rt for 2 h and concentrated to afford 3-((4-methoxybutoxy)(phenyl)methyl)pyrrolidine hydrochloride (41.3 mg, quant) as an oil.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-c58e928a5cae42e3bb83473d3d660d21
Source dataset
uspto-grants-2011_01
Patent number
US07872028B2

Reaction notes

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