HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2R,3S)-3-amino-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H-fluoren-9-yl)methoxycarbonyl)-amino)butan-2-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H-fluoren-9-yl)methoxycarbonyl)amino)butan-2-ol | HCID 57786493 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (2R,3S)-3-amino-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H-fluoren-9-yl)methoxycarbonyl)-amino)butan-2-ol hydrochloride | HCID 66861385 | — |
Reaction Steps
(2R,3S)-3-(t-Butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H-fluoren-9-yl)methoxycarbonyl)amino)butan-2-ol (255.3 mg, 0.39 mmol) was dissolved in 4 M HCl in dioxane (5 mL) and stirred at rt for 1 h. Removal of the solvent afforded (2R,3S)-3-amino-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H-fluoren-9-yl)methoxycarbonyl)-amino)butan-2-ol hydrochloride (253 mg, quant) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07872028B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-2d6552287ba04a7e884b80be268f3a1a |
| Source note | uspto-grants-2011_01 |