HRID253564

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1cc(CN(C[C@@H](O)[C@H](CC2CCCCC2)NC(=O)OC(C)(C)C)C(=O)OCC2c3ccccc3-c3ccccc32)cc(OC)c1

HCID57786493

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CN(C[C@@H](O)[C@@H](N)CC2CCCCC2)C(=O)OCC2c3ccccc3-c3ccccc32)cc(OC)c1.Cl

HCID66861385

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

(2R,3S)-3-(t-Butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H-fluoren-9-yl)methoxycarbonyl)amino)butan-2-ol (255.3 mg, 0.39 mmol) was dissolved in 4 M HCl in dioxane (5 mL) and stirred at rt for 1 h. Removal of the solvent afforded (2R,3S)-3-amino-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H-fluoren-9-yl)methoxycarbonyl)-amino)butan-2-ol hydrochloride (253 mg, quant) as a white solid.

WORKUP

后处理

customRemoval of the solvent

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2d6552287ba04a7e884b80be268f3a1a
来源数据集: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07872028B2
来源说明: uspto-grants-2011_01

反应 SMILES

C(OC([NH:8][C@@H:9]([CH2:42][CH:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1)[C@H:10]([OH:41])[CH2:11][N:12]([CH2:30][C:31]1[CH:36]=[C:35]([O:37][CH3:38])[CH:34]=[C:33]([O:39][CH3:40])[CH:32]=1)[C:13]([O:15][CH2:16][CH:17]1[C:29]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:23]2[C:18]1=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:14])=O)(C)(C)C.[ClH:49]>O1CCOCC1>[ClH:49].[NH2:8][C@@H:9]([CH2:42][CH:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1)[C@H:10]([OH:41])[CH2:11][N:12]([CH2:30][C:31]1[CH:36]=[C:35]([O:37][CH3:38])[CH:34]=[C:33]([O:39][CH3:40])[CH:32]=1)[C:13]([O:15][CH2:16][CH:17]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=2[C:24]2[C:29]1=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:14]