Lithium Hydroxide → Lithium 2-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)acetate

Participants

Reaction Steps

Methyl 2-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)acetate (19 mg, 0.0567 mmol) was mixed with a 1:1 mixture of 2 N aq LiOH (2 mL) and methanol (2 mL). The mixture was stirred overnight at r.t. LC-MS indicated the reaction was complete. The mixture was concentrated and the crude product was used without purification. LC-MS (3 min) tR=1.05 min, m/z 322 (M+1).

Provenance & Evidence