Lithium Hydroxide → Lithium 2-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)acetate

HRID 253603Notes

Reaction equation

HRID 253603 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][CH:7]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([CH2:14][C:15]([O:17]C)=[O:16])[CH2:9]1.[Li+:25].[OH-]>CO>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][CH:7]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([CH2:14][C:15]([O-:17])=[O:16])[CH2:9]1.[Li+:25]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 57786482Methyl 2-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)acetate

Product 1

HCID 57786491Lithium 2-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)acetate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 2-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)acetate (19 mg, 0.0567 mmol) was mixed with a 1:1 mixture of 2 N aq LiOH (2 mL) and methanol (2 mL). The mixture was stirred overnight at r.t. LC-MS indicated the reaction was complete. The mixture was concentrated and the crude product was used without purification. LC-MS (3 min) tR=1.05 min, m/z 322 (M+1).

Workup

  1. concentrationThe mixture was concentrated
  2. customthe crude product was used without purification
  3. customLC-MS (3 min) tR=1.05 min, m/z 322 (M+1)

Sources & evidence

ORD record
ord-726d1002edb246008d233b34989b0b0c
Source dataset
uspto-grants-2011_01
Patent number
US07872028B2

Reaction notes

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