反应详情

The product from Example 28A (50 mg, 0.14 mmol) in dioxane (5 mL) was treated with NaH (60%) (7 mg, 0.17 mmol) stirred at rt for 10 min and treated with isopropyl methanesulfonate (78 mg, 0.56 mmol). The reaction was heated at 85° C. for 12 hrs, quenched with H2O, the mixture was extracted with EtOAc (2×). The combined organic layers were dried over MgSO4, filtered and concentrated. The residue was purified by column chromatography using an Analogix® Intelliflash280™ (SiO2, 0-50% Hexane in ethyl acetate) to afford 5.2 mg (9%) of the title compound. 1H NMR (400 MHz, CDCl3) δ ppm 1.22 (d, J=6.14 Hz, 6H) 1.81 (s, 9H) 3.75-3.83 (m, 1H) 4.12 (s, 3H) 4.92 (s, 2H) 7.10 (d, J=9.21 Hz, 1H) 7.63 (dd, J=9.21, 2.76 Hz, 1H) 8.18 (d, J=2.45 Hz, 1H) 9.28 (s, 1H); MS (DCI/NH4+) m/z 397 (M+H)+.

1. temperatureThe reaction was heated at 85° C. for 12 hrs
2. customquenched with H2O
3. extractionthe mixture was extracted with EtOAc (2×)
4. dry with materialThe combined organic layers were dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was purified by column chromatography