Hexanal → HCID 86626354, compound

HRID 253666Notes

Reaction equation

HRID 253666 reaction equation
Cl.[F:2][CH2:3][C:4]([CH3:7])([NH2:6])[CH3:5].S([O-])([O-])(=O)=O.[Mg+2].C(=O)([O-])[O-].[K+].[K+].[CH:20](=O)[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>ClCCl>[F:2][CH2:3][C:4]([CH3:7])([N:6]=[CH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH3:5]

Participants

6

Reactant 4

HCID 6184HexanalHCID 11430Potassium CarbonateHCID 24083Sulfuric acid magnesium salt (1:1)HCID 139352511-Fluoro-2-methylpropan-2-amine hydrochloride

Product 1

HCID 86626354HCID 86626354, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of 1-fluoro-2-methylpropan-2-amine hydrochloride (ABCR) (2 g, 15.7 mmol), anhydrous magnesium sulfate (3.77 g, 31.4 mmol) and potassium carbonate (2.17 g, 15.68 mmol) in dichloromethane (100 mL) was added drop wise hexanal (1.93 mL, 15.7 mmol) at 0° C. The reaction mixture was stirred for 10 h at room temperature, then filtered and concentrated to obtain the title compound as a pale yellow liquid.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b2bbf89d50ee4843bff9f4b9df6c3bb8
Source dataset
uspto-grants-2011_01
Patent number
US07872033B2

Reaction notes

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