反应详情

A suspension of 100 g (0.26 mol) of dihydrofinasteride, 480 g of 20% HCl solution (2.63 mol) and 120 g of methanol are heated to reflux and boiled intensively for 8-12 hours. The reactant goes into solution on heating; after 8 hours, there is a suspension which can be readily filtered. The filtercake is washed three times intensively with 100 g each time of water, suction-dried for approx. 15 minutes and subsequently dried overnight. Yield: 60 g.

1. temperatureare heated
2. temperatureto reflux
3. temperatureon heating
4. waitafter 8 hours
5. filtrationcan be readily filtered
6. washThe filtercake is washed three times intensively with 100 g each time of water
7. customsuction-dried for approx. 15 minutes and subsequently dried overnight