Dithioerythritol → 1-(1-Acetyl-piperidin-4-yl)-3-[5-(2-azepan-1-yl-ethylsulfanyl)-thiazol-2-yl]-1-cyclohexyl urea

HRID 253900Notes

Reaction equation

HRID 253900 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:19][C:20]#N)=[CH:17][N:18]=2)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].SC[C@@H]([C@@H](CS)O)O.[N:36](=[CH:44]CCl)[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]Cl>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([CH:22]2[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][CH2:44][N:36]3[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]3)=[CH:17][N:18]=2)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 439352DithioerythritolHCID 534452782-(Hexamethyleneimino)ethyl chlorideHCID 866111901-(1-Acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea

Product 1

HCID 578837311-(1-Acetyl-piperidin-4-yl)-3-[5-(2-azepan-1-yl-ethylsulfanyl)-thiazol-2-yl]-1-cyclohexyl urea

Procedure

Prepared as described in general procedures (H) and (I) using 1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and 2-(hexamethyleneimino)ethylchloride

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8b484f7758bd48feadaaca6b3416cb56
Source dataset
uspto-grants-2011_01
Patent number
US07872139B2

Reaction notes

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