反应详情

温度

120 °C

To a solution of 5-bromo-2-chloro-3-(5-(2,3-dichlorophenyl)-1,2,3-thiadiazol-4-yl)pyridine (0.37 g, 0.88 mmol) in dioxane (2 mL) was added 4-methoxybenzylamine (4 eq, 460 μL, 3.5 mmol). The solution was heated in a sealed tube at 120° C. for 18 h. After cooling, the mixture was filtered and the filtrate was reduced in vacuo. The resulting oil was purified by silica gel chromatography (5 to 70% EtOAc/hexanes) to provide N-(4-methoxybenzyl)-5-bromo-3-(5-(2,3-dichlorophenyl)-1,2,3-thiadiazol-4-yl)pyridin-2-amine as a yellow sticky solid (415 mg, 90% yield)

1. temperatureAfter cooling
2. filtrationthe mixture was filtered
3. customThe resulting oil was purified by silica gel chromatography (5 to 70% EtOAc/hexanes)