反应详情

温度

102 °C

A solution of 2,3-di(2-methanesulfonyloxyethyl)furan (114 mmol) in dioxane (168 mL) is treated with potassium carbonate (337 mmol) and benzyl amine (70.1 mmol) and heated to 102° C. for 18 hours. The reaction is cooled, the precipitate removed by filtration, and the mother liquor concentrated to give a crude oil which is purified by silica chromatography (EtOAc/hexanes eluant) to provide 6-benzyl-5,6,7,8-tetrahydro-4H-furo[3,2-d]azepine.

1. temperatureThe reaction is cooled
2. customthe precipitate removed by filtration
3. concentrationthe mother liquor concentrated
4. customto give a crude oil which
5. customis purified by silica chromatography (EtOAc/hexanes eluant)