Sodium Hydroxide → HCID 66842981, compound

HRID 254103Notes

Reaction equation

HRID 254103 reaction equation
Cl.[NH2:2][C@H:3]([CH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:4]([O:6]CC)=[O:5].[OH-].[Na+:18]>CO.O>[NH2:2][C@H:3]([CH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:4]([O-:6])=[O:5].[Na+:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66842937HCID 66842937, compound

Product 1

HCID 66842981HCID 66842981, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Ethyl (2R)-2-amino-4-cyclohexylbutanoate hydrochloride (4.00 g, 18.75 mmol) was dissolved in MeOH/Water (10/5 ml). Sodium hydroxide (1.50 g, 37.50 mmol) was added. The reaction mixture was stirred for 1 h and concentrated to give the title compound as a colourless solid (containing 100 mol % of sodium chloride). 1H NMR [(CD3)2SO), 400 MHz] δ0.83-0.97 (m, 2H), 1.10-1.33 (m, 6H), 1.48-1.78 (m, 7H), 3.15 (dd, 1H).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-16dfbe28adbb45608b9e3533ff4ae89b
Source dataset
uspto-grants-2011_01
Patent number
US07871998B2

Reaction notes

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