HCID 59321321, compound → HCID 66862726, compound

HRID 254283Notes

Reaction equation

HRID 254283 reaction equation
[CH:1]1([C:7]2[N:8]([C:13]3[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=3[N+:20]([O-])=O)[CH:9]=[C:10]([CH3:12])[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>C(O)C.[Ni]>[CH:1]1([C:7]2[N:8]([C:13]3[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=3[NH2:20])[CH:9]=[C:10]([CH3:12])[N:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 59321321HCID 59321321, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66862726HCID 66862726, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Conditions

Temperature
42.5 °C

Procedure

3.03 g 2-(2-Cyclohexyl-4-methyl-imidazol-1-yl)-4-fluoro-nitrobenzene (10 mmol) were dissolved in 50 ml ethanol, 0.5 g Raney-Nickel was added and the mixture was heated 5 hours in a closed vessel at 40-45° C. and 10 bar hydrogen. After cooling the catalyst was removed and the filtrate was distilled to dryness.

Workup

  1. temperatureAfter cooling the catalyst
  2. customwas removed
  3. distillationthe filtrate was distilled to dryness

Sources & evidence

ORD record
ord-c2a018849c254c529a67ca4bec83e17d
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

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