HCID 66862366, compound → HCID 66862546, compound

HRID 254287Notes

Reaction equation

HRID 254287 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[C:4]([N:11]2[CH:15]=[C:14]([CH3:16])[N:13]=[C:12]2[CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:3]=1.[H][H]>[Ni].C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([N:11]2[CH:15]=[C:14]([CH3:16])[N:13]=[C:12]2[CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[CH:3]=1

Participants

5

Reactant 2

HCID 66862366HCID 66862366, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66862546HCID 66862546, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

3.2 g 4-Chloro-2-(2-cyclohexyl-4-methyl-imidazol-1-yl)-nitrobenzene, 50 ml ethanol, and 0.5 g Raney-Nickel were heated in a closed vessel with 10 bar hydrogen at 40-45° C. The catalyst was filtered off and the solvent was removed by distillation.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed by distillation

Sources & evidence

ORD record
ord-490efb7af3ec43bf8a1f9b3cf1b6034f
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

Loading…