4-Chloro-2-fluoro-1-nitrobenzene → 1-(2,5-Dichlorophenyl)-3,4-dimethylimidazo[1,5-a]quinoxaline

HRID 254311Notes

Reaction equation

HRID 254311 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]1[N:13]2[C:14]3[C:19]([N:20]=[C:21]([CH3:22])[C:12]2=[C:11]([CH3:24])[N:10]=1)=[CH:18][CH:17]=[C:16](F)[CH:15]=3.FC1C=C(Cl)C=CC=1[N+]([O-])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]1[N:13]2[C:14]3[C:19]([N:20]=[C:21]([CH3:22])[C:12]2=[C:11]([CH3:24])[N:10]=1)=[CH:18][CH:17]=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 696914-Chloro-2-fluoro-1-nitrobenzeneHCID 426292291-(2,5-Dichlorophenyl)-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline

Product 1

HCID 426294781-(2,5-Dichlorophenyl)-3,4-dimethylimidazo[1,5-a]quinoxalineYield 30%

Procedure

1-(2,5-Dichlorophenyl)-3,4-dimethylimidazo[1,5-a]quinoxaline was synthesized in a manner similar to 1-(2,5-dichlorophenyl)-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline starting with 2-fluoro-4-chloronitrobenzene. A white solid was recovered (0.04 g) 30% yield. MS (ES) m/z 342.0 [M+1]+

Workup

  1. customA white solid was recovered (0.04 g) 30% yield

Sources & evidence

ORD record
ord-230094960cb046d79e732c95be49b2c7
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

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