Dimethylformamide → HCID 42629829, compound

HRID 254316Notes

Reaction equation

HRID 254316 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]2[C:13]3[C:18]([N:19]=[C:20]([CH3:21])[C:11]2=[C:10]([CH3:23])[N:9]=1)=[CH:17][C:16]([OH:22])=[CH:15][CH:14]=3.C(=O)([O-])[O-].[Cs+].[Cs+].[CH3:30]N(C)C=O.Cl.Cl[C:37]1[C:46](C)=[CH:45][C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[N:38]=1>O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]2[C:13]3[C:18]([N:19]=[C:20]([CH3:21])[C:11]2=[C:10]([CH3:23])[N:9]=1)=[CH:17][C:16]([O:22][CH2:30][C:37]1[CH:46]=[CH:45][C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[N:38]=1)=[CH:15][CH:14]=3

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 10796Cesium carbonateHCID 42629710HCID 42629710, compoundHCID 86630794HCID 86630794, compound

Product 1

HCID 42629829HCID 42629829, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

1 g 1-(2-Chloro-phenyl)-3,4-dimethyl-7-hydroxy-imidazo(1,5-a)quinoxaline, 2.24 g Caesium carbonate, 50 mL N,N-dimethylformamide, 6 mL water, and 0.86 g 2-Chloro-methylquinoline hydrochloride were stirred for 3 h at 130° C. The reaction mixture was given into 150 mL water, filtered off, washed with water, dried under reduced pressure, and purified with silica gel, dichloromethane/methanol=95/5.

Workup

  1. filtrationfiltered off
  2. washwashed with water
  3. customdried under reduced pressure
  4. custompurified with silica gel, dichloromethane/methanol=95/5

Sources & evidence

ORD record
ord-4fa1b5ba194f400e96ec4737ded15627
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

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