Methyl Acrylate → HCID 12469800, compound

HRID 254329Notes

Reaction equation

HRID 254329 reaction equation
[NH2:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[C:8]([O:12][CH3:13])(=[O:11])[CH:9]=[CH2:10]>CO>[CH3:13][O:12][C:8](=[O:11])[CH2:9][CH2:10][NH:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 166581-Aminopiperidine

Product 1

HCID 12469800HCID 12469800, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1-aminopiperidine (100 g, 1.00 mol) in dry methanol at 0° C., methyl acrylate (99.0 ml, 1.10-mol) was added dropwise. The resulting mixture was stirred at room temperature overnight. After evaporation of the solvent, heptane was added to the residue, and the white solid (impurity) removed by filtration. The filtrate was concentrated to dryness to afford 80.0 g (43%) of the title compound as a yellow oil.

Workup

  1. customAfter evaporation of the solvent, heptane
  2. additionwas added to the residue
  3. customthe white solid (impurity) removed by filtration
  4. concentrationThe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-e61f7262045e42a6ba6e6b32893602c4
Source dataset
uspto-grants-2011_01
Patent number
US07875626B2

Reaction notes

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