Diisopropylethylamine → HCID 66858534, compound

HRID 254404Notes

Reaction equation

HRID 254404 reaction equation
CCN(C(C)C)C(C)C.Cl[C:11]([OH:13])=[O:12].[Cl:14][CH2:15][CH2:16][CH3:17].[N:18]1([C:24](=[O:26])[CH3:25])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>ClCCl>[Cl:14][CH2:15][CH2:16][CH2:17][O:13][C:11]([N:21]1[CH2:22][CH2:23][N:18]([C:24](=[O:26])[CH3:25])[CH2:19][CH2:20]1)=[O:12]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 837951-AcetylpiperazineHCID 86607520HCID 86607520, compound

Product 1

HCID 66858534HCID 66858534, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N,N′-diisopropylethylamine (0.10 mL, 6 mmol), followed by 3-chloropropane chloroformate (47.1 mg, 0.3 mmol) was added to a 5 mL glass vial containing 1-piperazin-1-yl-ethanone (38 mg, 0.3 mmol) dissolved in dichloromethane (1 mL). The reaction mixture was shaken at room temperature for about 0.5 h, then evaporated in vacuo to yield the title intermediate as an oily residue which was used without further treatment.

Workup

  1. customevaporated in vacuo

Sources & evidence

ORD record
ord-66a00961e2854901b4ca9e36261737c1
Source dataset
uspto-grants-2011_01
Patent number
US07875629B2

Reaction notes

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