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HRID254447

反应详情

EQUATION

反应方程式

HRID 254447 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[Si](C)(C)OCCCBr
HCID607486

(3-Bromopropoxy)-tert-butyldimethylsilane

C9H21BrOSi

结构：FC(F)(F)c1ccc([C@@]23CNC[C@@H]2C3)cc1
HCID59337591

(1S,5R)-1-[4-(Trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

C12H12F3N

PRODUCTS

生成物

1
结构：OCCCN1C[C@@H]2C[C@]2(c2ccc(C(F)(F)F)cc2)C1
HCID59337594

未命名化合物

收率 57.8%

PROCEDURE

实验过程

The title compound (66 mg yield) was prepared in analogy to the procedure described in Preparation 4 and Preparation 5 starting from (1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane (97 mg, 0.4 mmol), and [(3-bromopropyl)oxy](1,1-dimethylethyl) dimethylsilane (152 mg, 0.6 mmol).