HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromopropoxy)(tert-butyl)dimethylsilane → 3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}-1-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromopropoxy)(tert-butyl)dimethylsilane | HCID 607486 | — |
| Reactant | (1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane | HCID 59337591 | — |
| Product | 3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}-1-propanol | HCID 59337594 | 57.8% |
Reaction Steps
The title compound (66 mg yield) was prepared in analogy to the procedure described in Preparation 4 and Preparation 5 starting from (1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane (97 mg, 0.4 mmol), and [(3-bromopropyl)oxy](1,1-dimethylethyl) dimethylsilane (152 mg, 0.6 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875643B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-363f40b8a7a44f76a5e982c9f3d8b8ee |
| Source note | uspto-grants-2011_01 |