Ethylenediamine → 2-(2,6-Bis-trifluoromethyl-benzyl)-4,5-dihydro-1H-imidazole

HRID 254478Notes

Reaction equation

[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]([F:12])([F:11])[F:10])[C:4]=1[CH2:13][C:14]#[N:15].[CH2:18](N)[CH2:19][NH2:20]>>[F:1][C:2]([F:16])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]([F:10])([F:11])[F:12])[C:4]=1[CH2:13][C:14]1[NH:20][CH2:19][CH2:18][N:15]=1

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 589518382-(2,6-Bis(trifluoromethyl)phenyl)acetonitrile

Product 1

HCID 589516762-(2,6-Bis-trifluoromethyl-benzyl)-4,5-dihydro-1H-imidazole

Procedure

2-(2,6-Bis-trifluoromethyl-benzyl)-4,5-dihydro-1H-imidazole was prepared from (2,6-bis-trifluoromethyl-phenyl)-acetonitrile and ethylene diamine in analogy to Example 19 b): colourless crystals; MS (EI): 296.2 (M+.), 275.1 ((M-F)+.), 267.1 ((M-C2H5)+.), 227.1 (((M-imidazoline)+.), 100%).

Sources & evidence

ORD record: ord-9bc0b26fa98a4dd7b8d3095a5da5931d
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Reaction notes

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