Trimethylsilyl cyanide → HCID 58951712, compound

HRID 254491Notes

Reaction equation

Br[CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[F:12])[CH2:3][CH3:4].C[Si]([C:17]#[N:18])(C)C>>[F:12][C:6]1[C:7]([F:11])=[CH:8][CH:9]=[CH:10][C:5]=1[CH:2]([CH2:3][CH3:4])[C:17]#[N:18]

Participants

Reactant 2

HCID 82115Trimethylsilyl cyanide

HCID 58951777HCID 58951777, compound

Product 1

HCID 58951712HCID 58951712, compound

Procedure

rac-2-(2,3-Difluoro-phenyl)-butyronitrile was prepared from rac-1-(1-bromo-propyl)-2,3-difluoro-benzene and trimethylsilyl cyanide in analogy to Example 23 c): colourless oil.

Sources & evidence

ORD record: ord-8b2c7d3945004c6ba984b38dc75e0aed
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Reaction notes

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