Trimethylsilyl cyanide → HCID 58951881, compound

HRID 254495Notes

Reaction equation

HRID 254495 reaction equation
Br[CH:2]([C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[F:12])[CH2:3][CH3:4].C[Si]([C:17]#[N:18])(C)C>>[F:12][C:6]1[CH:7]=[CH:8][C:9]([F:11])=[CH:10][C:5]=1[CH:2]([CH2:3][CH3:4])[C:17]#[N:18]

Participants

3

Reactant 2

HCID 82115Trimethylsilyl cyanideHCID 58951841HCID 58951841, compound

Product 1

HCID 58951881HCID 58951881, compound

Procedure

rac-2-(2,5-Difluoro-phenyl)-butyronitrile was prepared from rac-2-(1-bromo-propyl)-1,4-difluoro-benzene and trimethylsilyl cyanide in analogy to Example 23 c): colourless oil.

Sources & evidence

ORD record
ord-3cc86c0ccff94c358cb043cfe61270b4
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

Loading…