Ethylenediamine → HCID 58951787, compound

HRID 254530Notes

Reaction equation

HRID 254530 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[C:5]([CH3:12])[C:4]=1[CH3:13].[CH3:14]I.[CH2:16]([NH2:19])[CH2:17][NH2:18]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:16])[C:10]#[N:11])=[C:5]([CH3:12])[C:4]=1[CH3:13].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:14]2[NH:18][CH2:17][CH2:16][N:19]=2)[CH3:10])=[C:5]([CH3:12])[C:4]=1[CH3:13]

Participants

5

Reactant 3

HCID 3301EthylenediamineHCID 6328Methyl iodideHCID 5948942,3-Dimethyl-4-methoxyphenylacetonitrile

Product 2

HCID 58951787HCID 58951787, compoundHCID 66855993HCID 66855993, compound

Procedure

rac-2-(4-Methoxy-2,3-dimethyl-phenyl)-propionitrile which was prepared from 2-(4-methoxy-2,3-dimethyl-phenyl)-acetonitrile and methyl iodide in analogy to Example 65a) was reacted with ethylenediamine to form rac-2-[1-(4-methoxy-2,3-dimethyl-phenyl)-ethyl]-4,5-dihydro-1H-imidazole in analogy to Example 19b; isolated as hydrochloride: white powder; MS (EI): 233.3 ((M+.).

Sources & evidence

ORD record
ord-917333c3fd0f490183d9fb20a412fb32
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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