Ethylacetate heptane → 2-Ethyl-3,6-difluoro-benzaldehyde

HRID 254571Notes

Reaction equation

C(/N=[CH:6]/[C:7]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([F:14])[C:8]=1[CH2:15][CH3:16])CCC.C(OCC)(=[O:19])C.CCCCCCC>>[CH2:15]([C:8]1[C:9]([F:14])=[CH:10][CH:11]=[C:12]([F:13])[C:7]=1[CH:6]=[O:19])[CH3:16]

Participants

Reactant 2

HCID 21899848Ethylacetate heptane

HCID 178448986HCID 178448986, compound

Product 1

HCID 589519022-Ethyl-3,6-difluoro-benzaldehyde

Procedure

2-Ethyl-3,6-difluoro-benzaldehyde was prepared from butyl-[1-(2-ethyl-3,6-difluoro-phenyl)-meth-(E)-ylidene]-amine by flash chromatography (silica gel, ethyl acetate/heptane gradient): yellow oil; 1H-NMR (CDCl3): 1.22 (3H, t, CH3), 3.02 (2H, m, CH2), 6.99 (1H, ddd, ArH), 7.23 (1H, ddd, ArH), 10.45 (1H, d, CH═O).

Sources & evidence

ORD record: ord-b0192905c2dd4bbb950f289d8ded8df9
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Reaction notes

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