Ethylenediamine → 2-(2-Ethyl-3,6-difluoro-benzyl)-4,5-dihydro-1H-imidazole

HRID 254573Notes

Reaction equation

HRID 254573 reaction equation
Br[C:2](Br)=[CH:3][C:4]1[C:9]([CH2:10][CH3:11])=[C:8]([F:12])[CH:7]=[CH:6][C:5]=1[F:13].[CH2:15]([NH2:18])[CH2:16][NH2:17]>>[CH2:10]([C:9]1[C:8]([F:12])=[CH:7][CH:6]=[C:5]([F:13])[C:4]=1[CH2:3][C:2]1[NH:17][CH2:16][CH2:15][N:18]=1)[CH3:11]

Participants

3

Reactant 2

HCID 3301EthylenediamineHCID 589518562-(2,2-Dibromo-vinyl)-3-ethyl-1,4-difluoro-benzene

Product 1

HCID 589517482-(2-Ethyl-3,6-difluoro-benzyl)-4,5-dihydro-1H-imidazole

Procedure

2-(2-Ethyl-3,6-difluoro-benzyl)-4,5-dihydro-1H-imidazole was prepared from 2-(2,2-dibromo-vinyl)-3-ethyl-1,4-difluoro-benzene and ethylenediamine in analogy to Example 1e): yellow crystals; MS (ISP): 225.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-d31e599ce3fe4b8a9de51e3c0168bd59
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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