Benzyl Bromide → HCID 58951865, compound

HRID 254594Notes

Reaction equation

[CH2:1]([C:3]1[CH:10]=[C:9]([OH:11])[CH:8]=[C:7]([CH2:12][CH3:13])[C:4]=1[CH:5]=[O:6])[CH3:2].C(=O)([O-])[O-].[Cs+].[Cs+].[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:20]([O:11][C:9]1[CH:8]=[C:7]([CH2:12][CH3:13])[C:4]([CH:5]=[O:6])=[C:3]([CH2:1][CH3:2])[CH:10]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

Reactant 3

HCID 7498Benzyl Bromide

HCID 10796Cesium carbonate

HCID 54206997HCID 54206997, compound

Product 1

HCID 58951865HCID 58951865, compound

Procedure

4-Benzyloxy-2,6-diethyl-benzaldehyde was prepared from 2,6-diethyl-4-hydroxy-benzaldehyde, cesium carbonate and benzyl bromide in analogy to Example 213b): yellow oil; 1H-NMR (CDCl3): 1.25 (6H, t, 2×CH3), 2.98 (4H, q, 2×CH2), 5.12 (2H, s, OCH2), 6.72 (2H, s, 2×ArH), 7.33-7.45 (5H, m, Ph), 10.47 (1H, s, CH═O).

Sources & evidence

ORD record: ord-69704dcc18424b07ade48a36241ee999
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Reaction notes

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