反应详情

To a solution of ethyl 4-bromo-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate (68) (500 mg, 1.1 mmol) in aqueous toluene, tetrakis(triphenylphsophine)palladium (122 mg, 0.11 mmol) and potassium carbonate (510 mg, 3.9 mmol) were added. The reaction mixture was placed under microwave irradiation with the temperature set to 140° C. The resulting solution was filtered with syringe filter, and then solvent was evaporated under reduced pressure. The residue was purified with silica gel column chromatography to obtain the title compound (283 mg, 44%) as white solid.

1. customThe reaction mixture was placed under microwave irradiation with the temperature
2. customset to 140° C
3. filtrationThe resulting solution was filtered with syringe
4. filtrationfilter
5. customsolvent was evaporated under reduced pressure
6. customThe residue was purified with silica gel column chromatography