L-Tartaric acid → HCID 86622999, compound

Participants

Reaction Steps

A mixture of 4-(oxiran-2-ylmethoxy)-9H-carbazole (II) (25.0 g, 104.60 mmole) and 62.5 ml 2-propanol is heated to 70° C. to 80° C. To this 2-(2-methoxyphenoxy)ethylamine (III) (25.33 g, 151.67 mmole) is added in one lot. The temperature of reaction mass is raised to reflux (80° C. to 85° C.) and maintained at this temperature for 2 hour. After that, this reaction mass is added to the pre-heated (80° C. to 85° C.) solution of L(+) tartaric acid (24.32 g) (162.1 mmole) in 2-propanol (287.5 ml) and continued the reflux for next 1 hour, cooled to 50° C. to 55° C. and maintained for 1 hour. The product is filtered at the same temperature (50° C. to 55° C.) followed by three 33.5 ml wash with hot (50° C. to 55° C.) 2-Propanol. The wet product dried at 60° C. to 65° C. for 6-8 hours or till constant weight gave 33.0 g of Carvedilol tartarate (Yield 56.89%).

Provenance & Evidence