反应详情

A mixture of 4-(oxiran-2-ylmethoxy)-9H-carbazole (II) (25.0 g, 104.60 mmole) and 62.5 ml 2-propanol is heated to 70° C. to 80° C. To this 2-(2-methoxyphenoxy)ethylamine (III) (25.33 g, 151.67 mmole) is added in one lot. The temperature of reaction mass is raised to reflux (80° C. to 85° C.) and maintained at this temperature for 2 hour. After that, this reaction mass is added to the pre-heated (80° C. to 85° C.) solution of L(+) tartaric acid (24.32 g) (162.1 mmole) in 2-propanol (287.5 ml) and continued the reflux for next 1 hour, cooled to 50° C. to 55° C. and maintained for 1 hour. The product is filtered at the same temperature (50° C. to 55° C.) followed by three 33.5 ml wash with hot (50° C. to 55° C.) 2-Propanol. The wet product dried at 60° C. to 65° C. for 6-8 hours or till constant weight gave 33.0 g of Carvedilol tartarate (Yield 56.89%).

1. temperatureis heated to 70° C. to 80° C
2. customThe temperature of reaction mass
3. temperatureis raised
4. temperatureto reflux (80° C. to 85° C.)
5. temperaturemaintained at this temperature for 2 hour
6. additionAfter that, this reaction mass is added to the
7. temperaturereflux for next 1 hour
8. temperaturecooled to 50° C. to 55° C.
9. temperaturemaintained for 1 hour
10. filtrationThe product is filtered at the same temperature (50° C. to 55° C.)
11. washwash with hot (50° C. to 55° C.) 2-Propanol
12. customThe wet product dried at 60° C. to 65° C. for 6-8 hours or till constant weight