反应详情

A mixture of Carvedilol salicylate (36.0 g, 66.18 mmole) and 2-propanol (108 ml) is heated to 50° C. to 55° C. To this, a solution of sodium hydroxide (4.5 g) in water (36 ml) is added slowly in about 30 minutes. The solution is then stirred at 65° C. to 70° C. for 15 minutes and filtered, followed by two 18 ml wash with hot (55° C. to 60° C.) 2-propanol. The filtrate is cooled to 30° C. to 40° C., 18 ml of water is added and stirred at 25° C. to 35° C. for 3 hours. The precipitated product is filtered, followed by two 30 ml wash with water. The wet product dried at 50° C. to 55° C. till constant weight gives 24.5 g of Carvedilol (Yield=91.21%).

1. temperatureis heated to 50° C. to 55° C
2. filtrationfiltered
3. washwash with hot (55° C. to 60° C.) 2-propanol
4. temperatureThe filtrate is cooled to 30° C. to 40° C.
5. addition18 ml of water is added
6. stirringstirred at 25° C. to 35° C. for 3 hours
7. filtrationThe precipitated product is filtered
8. washwash with water
9. customThe wet product dried at 50° C. to 55° C. till constant weight