反应详情

温度

50 °C

The product from Example 1, Step B, 5-(1H-indol-2-yl)-2-methoxy-phenylamine (0.1765 g, 0.74 mmol) was mixed with 3,5-dichlorophenyl isothiocyanate (0.151 g, 0.74 mmol) in ethyl acetate (20 mL) and was heated briefly at 50° C. and then allowed to stand overnight at room temperature. The reaction mixture was concentrated to dryness, triturated with hexanes, and the insoluble material collected by filtration (0.169 g), mp 199-201° C.

1. concentrationThe reaction mixture was concentrated to dryness
2. customtriturated with hexanes
3. filtrationthe insoluble material collected by filtration (0.169 g), mp 199-201° C.