反应详情

Cyclohexene (1.5 mL) and Pd(OH)2/C (0.15 g) were added to a solution of compound 1 (0.3 g, 0.87 mmol) in ethanol (20 mL). The resultant mixture was stirred under a reflux temperature of 78° C. for 2 hrs, and then cooled to room temperature. After filtration, the filtrate was concentrated in vacuo, followed by purification via silica gel column chromatography (ethyl acetate/n-hexane=1:4), thus giving the title compound 3a as a colorless crystal (0.21 g, 94% yield).

1. filtrationAfter filtration
2. concentrationthe filtrate was concentrated in vacuo
3. customfollowed by purification via silica gel column chromatography (ethyl acetate/n-hexane=1:4)