HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethyl 4-methoxyphenyl ketone → 2-(5-Benzyloxy-2-vinylphenoxy)-1-(4-methoxyphenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethyl 4-methoxyphenyl ketone | HCID 4965 | — |
| Reactant | 4-Benzyloxy-2-hydroxybenzaldehyde | HCID 561235 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 4-Benzyloxy-2-[2-(4-methoxyphenyl)allyloxy]-1-vinylbenzene | HCID 59592106 | — |
| Product | 2-(5-Benzyloxy-2-vinylphenoxy)-1-(4-methoxyphenyl)ethanone | HCID 49821324 | 74% |
Reaction Steps
Alternatively, the compound 2 can be obtained by reacting 4-benzyloxy-2-hydroxybenzaldehyde with a mixture of MTPPB and t-BuOK, followed by reaction with 2-bromo-4′-methoxyacetophenone, and the resultant mixture, instead of being subjected to purification to afford compound 2a, was continuously reacted with a mixture of MTPPB and t-BuOK in THF, giving a one pot yield of 74%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875736B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-04e42c318f6241ceb779ed124bd91f80 |
| Source note | uspto-grants-2011_01 |