反应详情

温度

50 °C

The product from Example 3, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine, (0.137 g, 0.5 mmol) was mixed with 3,5-dichlorophenyl isothiocyanate (0.111 g, 0.54 mmol) in ethyl acetate (10 mL) and heated briefly to 50° C. and then allowed to stand overnight at room temperature. The reaction mixture was concentrated to dryness and triturated with hexanes/ethyl acetate, and the insoluble solid collected by filtration (0.214 g), mp 203-205° C.

1. concentrationThe reaction mixture was concentrated to dryness
2. customtriturated with hexanes/ethyl acetate
3. filtrationthe insoluble solid collected by filtration (0.214 g), mp 203-205° C.