Oxalyl chloride → HCID 23137896, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:13][CH3:14])[C:11]=1[CH3:12])[C:6]([OH:8])=O.C(Cl)(=O)C(Cl)=O.Cl.[CH3:22][NH:23][O:24][CH3:25]>>[CH3:25][O:24][N:23]([CH3:22])[C:6](=[O:8])[C:5]1[CH:9]=[C:10]([O:13][CH3:14])[C:11]([CH3:12])=[C:3]([O:2][CH3:1])[CH:4]=1Komponenten
Versuchsvorschrift
3,5-Dimethoxy-4-methylbenzoic acid was allowed to react with oxalyl chloride, and the resulting acid chloride was allowed to react with N,O-dimethylhydroxyamine hydrochloride to obtain N,3,5-trimethoxy-N,4-dimethylbenzamide. The resulting compound was allowed to react with 4-phenylbutylmagnesium chloride to obtain 1-(3,5-dimethoxy-4-methylphenyl)-5-phenylpentan-1-one. The resulting compound was allowed to react with lithium diisopropylaminez and methyl[4-(bromomethyl)phenyl]acetate in the presence of N,N,N′,N″,N″-pentamethyldiethylenetriamine to obtain methyl{4-[2-(3,5-dimethoxy-4-methylbenzolyl)-5-phenylpentyl]phenyl}acetate. Using the obtained compound, the procedure similar to Example 2 were carried out to give the title compound having the following physical properties.
Quellen und Nachweise
- ORD-Eintrag
- ord-b7c43a1a96b54d3ebf5f6e6d0fdb35a2
- Quelldatensatz
- uspto-grants-2011_01
- Patentnummer
- US07875745B2
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