反应详情

To a solution of 3-amino-5-nitrobenzoic acid (1.12 g, 6.16 mmol) in THF (5 mL) was added dropwise a solution of borane tetrahydrofuran complex solution (13.6 mL, 13.6 mmol) at ambient temperature and the mixture was stirred for 90 minutes. The solvent was then evaporated. Aqueous NaOH (15 mL) was added and the resulting mixture was extracted with ether. The ether solution was dried over anhydrous Na2SO4. Evaporation of ether afforded 921 mg of the title compound (89%).

1. customThe solvent was then evaporated
2. additionAqueous NaOH (15 mL) was added
3. extractionthe resulting mixture was extracted with ether
4. dry with materialThe ether solution was dried over anhydrous Na2SO4
5. customEvaporation of ether