Ethanol → HCID 178488275, compound

HRID 254982Notes

Reaction equation

HRID 254982 reaction equation
CO[C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8]([NH:10][N:11]=[C:12]([C:15]#[N:16])[C:13]#[N:14])[S:9][C:5]=2[CH:4]=1.C(#N)CC#N.O.[NH2:25][NH2:26].[CH2:27]([OH:29])C>>[CH3:27][O:29][C:18]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([NH:10][N:11]=[C:12]3[C:13]([NH2:14])=[N:26][N:25]=[C:15]3[NH2:16])=[N:7][C:6]=2[CH:17]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 8010MalononitrileHCID 24654Hydrazine hydrate (1:1)HCID 14930588HCID 14930588, compound

Product 1

HCID 178488275HCID 178488275, compound

Procedure

4-[(5-methoxybenzothiazol-2-yl)hydrazono]-4H-pyrazole-3,5-diamine was prepared using 2-[(6-methoxybenzothiazol-2-yl)hydrazono]malononitrile (200 mg), which was derived from 2-amino-6-methoxybensothiazole (1.17 g) and malononitrile (0.82 g), and hydrazine hydrate (0.2 mL) in ethanol. Solids had not formed after heating the reaction at 40° C. for 2 hrs. The solution was allowed to cool to ambient temperature and concentrated. The product was obtained after column chromatography purification (80 mg, 35%).

Workup

  1. customSolids had not formed
  2. temperatureafter heating
  3. customthe reaction at 40° C. for 2 hrs
  4. concentrationconcentrated
  5. customThe product was obtained
  6. customafter column chromatography purification (80 mg, 35%)

Sources & evidence

ORD record
ord-c6f93088e3764fb5a23a2f75b242d901
Source dataset
uspto-grants-2011_01
Patent number
US07875728B2

Reaction notes

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