Hydrochloric Acid → HCID 178434098, compound

HRID 255025Notes

Reaction equation

HRID 255025 reaction equation
C([O:3][C:4]([C:6]1[C:7]([NH:11][N:12]=[C:13]2[C:17]([CH3:18])=[N:16][N:15]=[C:14]2[NH2:19])=[N:8][NH:9][CH:10]=1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[NH2:19][C:14]1[C:13](=[N:12][NH:11][C:7]2[C:6]([C:4]([OH:5])=[O:3])=[CH:10][NH:9][N:8]=2)[C:17]([CH3:18])=[N:16][N:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178469937HCID 178469937, compound

Product 1

HCID 178434098HCID 178434098, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-[N′-(3-amino-5-methylpyrazol-4-ylidene)hydrazino]-1H-pyrazole-4-carboxylic acid was prepared by dissolving 3-[N′-(3-amino-5-methylpyrazol-4-ylidene)hydrazino]-1H-pyrazole-4-carboxylic acid ethyl ester (0.2 g, 0.8 mmol) in ethanol containing sodium hydroxide (0.2 g, 5 mmol) and the solution was stirred overnight. The mixture was then acidified to pH 1 with 1N hydrochloric acid and the resulting solid was isolated by filtration. The crude material was purified by preparative TLC eluting with (CHCl3:MeOH:H2O=4:1:0.005) to yield 39 mg (22%) of the compound as a red solid.

Workup

  1. customthe resulting solid was isolated by filtration
  2. customThe crude material was purified by preparative TLC
  3. washeluting with (CHCl3:MeOH:H2O=4:1:0.005)

Sources & evidence

ORD record
ord-fecf386f20ff48ad9a69e0a32fb2c813
Source dataset
uspto-grants-2011_01
Patent number
US07875728B2

Reaction notes

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