Dimethylformamide → HCID 178434096, compound

HRID 255028Notes

Reaction equation

HRID 255028 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])([O-:3])=[O:2].[NH2:11][C:12]1[CH:16]=[C:15]([CH3:17])[NH:14][N:13]=1.C[N:19](C=O)C>O>[CH3:17][C:15]1[C:16](=[N:19][NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[C:12]([NH2:11])=[N:13][N:14]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 74233-NitroanilineHCID 931461H-Pyrazol-3-amine, 5-methyl-

Product 1

HCID 178434096HCID 178434096, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-methyl-4-[(3-nitrophenyl)hydrazono]-4H-pyrazol-3-ylamine was prepared from 3-nitroaniline (0.35 g, 2.5 mmol) and 3-amino-5-methylpyrazole (0.3 g, 3.1 mmol) according to the procedure described above except that the substituted aniline was initially dissolved in a mixture of water (3.6 mL) and DMF (2.0 mL) prior to being acidified. The product was isolated in a yield of 176 mg (29%) of the compound as a red solid and was not further purified. MS (m/z, ES+): 247.2 (M+1, 100%).

Sources & evidence

ORD record
ord-2669a4ece7a649a3ade382d032deca78
Source dataset
uspto-grants-2011_01
Patent number
US07875728B2

Reaction notes

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